Definition

Urea is the chief end product the protein metabolism. Created in the liver from ammonia and excreted through the kidneys, urea constitutes 40% come 50% that the blood’s nonprotein nitrogen. Since the level of reabsorption the urea in the renal tubules is straight related come the rate of urine circulation through the kidneys, the blood urea nitrogen (BUN) level is less reliable indicator or uremia than is the serum creatinine level. The BUN test procedures the nitrogen fraction.

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Purpose To confirm bacterecemia.To determine causative organism in bacterecemia and also septicemia.To recognize the cause of fever with an unknown origin.ProcedurePatient PreparationTell the patient the the BUN test is offered to advice kidney function.Inform the patient that he require not come restrict food and also fluids, however should protect against diet high in meat.Tell the patient the the test needs a blood sample. Define who will do the venipuncture and also when.Explain come the patient the he might experience slight uncomfortable from the tourniquet and also needle puncture.Notify the laboratory and physician of medications the patient is taking that may impact test results; they might need to it is in restricted.ImplementationClean the venipuncture site very first with one alcohol swab and then v a providone-iodine swab, starting at the site and also working outward in a circular motion.Wait at the very least 1 minute for the skin come dry.Perform a venipuncture and draw 10 to 20 ml of blood for an adult, or 2 to 6 ml for a child.Clean the diaphragm tops of the culture bottles through alcohol or iodine and readjust the needle on the syringe.If using broth, add blood to every bottle until achieving a 1:5 or 1:10 dilution.


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For example, add 10 ml that blood to a 100-ml bottle. Keep in mind that the size of the bottle may vary depending on hospital protocol.If making use of a unique resin, add blood to the resin in the bottles according to facility protocol, and also invert tenderness to mix it.Draw the blood directly into distinct collection processing tube if making use of lysis-centrifugation method (Isolator).Document the tentative diagnosis and current or current antimicrobial treatment on the laboratory request.Send every sample to the laboratory immediately.Collect blood cultures before giving antimicrobial agents whenever possible because vault or current antimicrobial therapy may provide false-negative results.To detect most causative agents, it’s finest to execute the blood societies on 2 consecutive days.Nursing InterventionsUse alcohol to remove the iodine native the venipuncture site.Monitor the venipuncture site for bleeding and signs that infection.InterpretationsNormal ResultsBUN values typically range type 8 to 20 mg/dl (SI, 2.9 come 7.5 mmol/L)In yonsei patients, BUN will show slightly higher values, possibly to 69 mg/dl (SI, 25.8 mmol/L).Abnormal ResultsElevated BUN levels occurs in renal disease, diminished renal blood circulation (due come dehydration), urinary street obstruction, and increased protein catabolism (such as with burns).Low BUN levels happen in major hepatic damage, malnutrition, and also overhydration.Interfering FactorsHemolysis from rough handling of the sample.Use that chloramphenicol may feasible decrease the BUN.Aminoglycosides, amphoterecin B, and methicillin may rise BUN by nephrotoxicity.ComplicationsHematoma at the puncture site.PrecautionHandle the sample tenderness to stop hemolysis.