Medically the review by Alan Carter, Pharm.D. — composed by college of Illinois — update on respectable 29, 2018

Introduction

If you’re in pain, you want a drug that’s walk to aid you feeling better. 3 prescription pain medicine you may have actually heard of room tramadol, oxycodone, and oxycodone CR (controlled release). These drugs are provided to treat moderate to severe pain. They belong come a class of drugs dubbed opioid analgesics, which work-related in your mind to change how your body feels and responds to pain.

If your doctor prescribes among these drugs for you, they’ll tell girlfriend what to mean with her treatment. Yet if you’re curious about how these drugs compare to every other, this article looks in ~ tramadol, oxycodone, and also oxycodone CR side-by-side. It provides you in-depth information friend can comment on with her doctor. Together, you and also your medical professional can discover if among these medicine is a great match for her pain treatment needs.

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The table listed below provides basic information about tramadol, oxycodone, and also oxycodone CR. Oxycodone come in 2 forms: an immediate-release (IR) tablet computer and a controlled-release (CR) tablet. The IR tablet releases the medication right into your body appropriate away. The CR tablet releases the medication end a 12-hour period. Oxycodone CR tablet computers are used when you need continuous pain medication because that a long duration of time.


Generic nameTramadol Oxycodone Oxycodone CR
What room the brand-name versions?Conzip, Ultram, Ultram ER (extended release)Oxaydo, RoxicodoneOxycontin
Is a generic variation available?YesYesYes
Why is that used?Treatment the moderate to moderately significant painTreatment of center to significant painTreatment of center to serious pain when constant pain management is needed
What form(s) does the come in?Immediate-release dental tablet, extended-release oral tablet, extended-release oral capsuleImmediate-release oral tabletControlled-release oral tablet
What room the strengths?Immediate-release dental tablet:• 50 mgExtended-release dental tablet:• 100 mg• 200 mg• 300 mgExtended-release oral capsule:• 100 mg• 150 mg• 200 mg• 300 mg• 5 mg• 10 mg• 15 mg• 20 mg• 30 mg• 10 mg• 15 mg• 20 mg• 30 mg• 40 mg• 60 mg• 80 mg
What dosage will certainly I take?Determined by your doctorDetermined by her doctor based upon your history of opioid useDetermined by her doctor based upon your background of opioid use
How long will ns take it?Determined by your physician Determined by her doctorDetermined by her doctor
How perform I keep it?Stored at a temperature in between 59°F and also 86°F (15°C and 30°C) Stored in ~ a temperature in between 68°F and 77°F (20°C and 25°C)Stored in ~ 77°F (25°C)
Is this a regulated substance?Yes*Yes*Yes*
Is there a danger of withdrawal? Yes†Yes†Yes†
Does it have actually potential for misuse?Yes¥Yes¥Yes¥

* A managed substance is a drug that is regulated by the government. If you take a controlled substance, your doctor must carefully supervise your usage of the drug. Never give a controlled substance the your doctor has prescribed because that you come anyone else. † If you’ve been taking this medicine for much longer than a few weeks, execute not prevent taking that without talking to your doctor. Girlfriend will must taper off the drug progressively to avoid withdrawal symptom such as anxiety, sweating, nausea, and also trouble sleeping. ¥ This drug has a high potential for misuse. This means you can get addicted come this drug. Be certain to take this drug specifically as your doctor tells friend to. If you have questions or concerns, talk with your doctor.

Learn more: Opioid misuse and addiction »


For each of this drugs, your physician will inspect your pains control and side results throughout her treatment. If your pain it s okay worse, your physician may boost your dosage. If her pain gets much better or walk away, your physician will gradually lower her dosage. This helps stop withdrawal symptoms.

Tramadol

Your doctor will likely start you at the lowest possible dosage and also increase it slowly. This helps alleviate side effects.

Oxycodone IR

Your doctor might start girlfriend on the lowest dosage the oxycodone. Castle may boost your dosage progressively to aid reduce next effects and also to discover the lowest dosage that works for you.

If you must take oxycodone around-the-clock to regulate chronic pain, her doctor might switch you to oxycodone CR twice a job instead. Breakthrough pain may be managed as needed with low-dose oxycodone or tramadol.

Oxycodone CR

Oxycodone CR deserve to only be supplied for continuous, long-term pain management. Girlfriend can’t usage it as an as-needed pains medication. This is because taking doses too closely together have the right to spike the amount of drug in her body. This can be deadly (cause death).

You should swallow oxycodone CR tablets whole. Do not break, chew, or to like the tablets. Taking broken, chewed, or crushed oxycodone CR tablets leads to a fast release that the medication the your human body absorbs quickly. This can cause a dangerous sheep of oxycodone that deserve to be fatal.


Like various other drugs, tramadol, oxycodone, and also oxycodone CR can cause side effects. Several of these side results are more common and may go away after a couple of days. Rather are an ext serious and also can require clinical care. You and your medical professional should consider all side results when deciding if a medicine is a an excellent choice because that you.

Examples of side results from tramadol, oxycodone, and oxycodone CR are listed in the table below.


Tramadol Oxycodone Oxycodone CR
More usual side effects• Nausea• Vomiting• Constipation• Dizziness• Drowsiness• Headache• Itching• lack of energy• Sweating• dried mouth• Nervousness• Indigestion• Nausea• Vomiting• Constipation• Dizziness• Drowsiness• Headache• Itching• absence of energy• trouble sleeping• Nausea• Vomiting• Constipation• Dizziness• Drowsiness• Headache• Itching• Weakness• Sweating• dry mouth
Serious side effects• Slowed breathing• Seizures• Serotonin syndromeAllergic reaction, v symptoms such as:• itching• hives• narrowing of your airway• rash that spreads and also blisters• skin peeling• ede of her face, lips, throat, or tongue• Slowed breathing• Shock• short blood pressure• no being able come breathe• Cardiac arrest (heart stops beating)Allergic reaction, with symptoms such as:• itching• hives• problem breathing• ede of her face, lips, or tongue• Slowed breathing• Shock• low blood pressure• not being able to breathe• Breathing the stops and also starts, generally during sleep

An communication is when a substance transforms the means a medicine works. This deserve to be harmful or prevent the medicine from functioning well. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. This can help your medical professional prevent feasible interactions.

Examples of drugs that may interact with tramadol, oxycodone, or oxycodone CR are listed in the table below.


TramadolOxycodoneOxycodone CR
Drug interactions• other pain medications such as morphine, hydrocodone, and fentanyl• Phenothiazines (drugs used to treat serious psychological disorders) such together chlorpromazine and also prochlorperazine• Tranquilizers such together diazepam and also alprazolam• sleeping pills such together zolpidem and temazepam• Quinidine• Amitriptyline• Ketoconazole• Erythromycin• Monoamine oxidase inhibitors (MAOIs) such as isocarboxazid, phenelzine, and also tranylcypromine• Serotonin norepinephrine reuptake inhibitors (SNRIs) such as duloxetine and venlafaxine• Selective serotonin reuptake inhibitors (SSRIs) such together fluoxetine and also paroxetine• Triptans (drugs that treat migraines/headaches) such together sumatriptan and zolmitriptan• Linezolid• Lithium• St. John’s wort• Carbamazepine• various other pain medications such together morphine, hydrocodone, and also fentanyl• Phenothiazines (drugs supplied to law serious mental disorders) such as chlorpromazine and prochlorperazine• Tranquilizers such together diazepam and also alprazolam• sleeping pills such as zolpidem and also temazepam• Butorphanol• Pentazocine• Buprenorphine• Nalbuphine• Monoamine oxidase inhibitors (MAOIs) such together isocarboxazid, phenelzine, and also tranylcypromine• bones muscle relaxants such together cyclobenzaprine and also methocarbamol• other pain medicines such as morphine, hydrocodone, and fentanyl• Phenothiazines (drugs provided to law serious psychological disorders) such as chlorpromazine and also prochlorperazine• Tranquilizers such as diazepam and alprazolam• sleeping pills such as zolpidem and also temazepam• Butorphanol• Pentazocine• Buprenorphine• Nalbuphine

Your as whole health is a aspect when considering if a medicine is a good choice for you. For instance, a certain drug might worsen a specific condition or an illness you have. Below are medical conditions you should discuss with your doctor before taking tramadol, oxycodone, or oxycodone CR.

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TramadolOxycodoneOxycodone CR
Medical problems to talk about with your doctor• respiratory (breathing) problems such together chronic obstructive pulmonary an illness (COPD)• Metabolic disorders such together thyroid problems and diabetes• history of misuse of drugs or alcohol• current or past alcohol or drug withdrawal• epidemic of the area about your mind and spinal cord• danger of suicide• Epilepsy, a history of seizures, or hazard of seizures• Kidney problems• Liver problems• respiratory tract (breathing) problems such as chronic obstructive pulmonary an illness (COPD)• low blood pressure• Head injuries• Pancreatic disease• Biliary tract disease• respiratory tract (breathing) conditions such together chronic obstructive pulmonary disease (COPD)• short blood pressure• Head injuries• Pancreatic disease• Biliary street disease

Tramadol, oxycodone, and oxycodone CR are powerful prescription pain medications. Among these drugs might be a good fit because that you. Talk with your doctor about:

your pain requirements your health background any medications and also supplements you take if you’ve taken opioid ache medications before or if you’re acquisition them now

Your physician will consider every one of these determinants to assess your pain needs and also choose the drug that’s best-suited for you.


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Medically reviewed by Alan Carter, Pharm.D. — written by university of Illinois — update on respectable 29, 2018