A methodical testimonial and meta-analysis

Yang, Fang MMa; Dong, Liang MMa; Zhang, Xiaojin MMb; Li, Junjun MMa; Tan, Kun MMa; Li, Yulin MMb; Yu, Xujun PhDb,∗

Author Indevelopment

aDepartment of Andrology, The Refertile & Women-Children Hospital, Chengdu University of Timeless Chinese Medicine, Chengdu, Sichuan, P. R. China

bChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, P. R. China.

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∗Correspondence: Xujun Yu, Chengdu College of Traditional Chinese Medicine, Chengdu, Sichuan, P. R. China 610041 (e-mail: ).

Abbreviations: CI = confidence interval, IIEF-5 = Internationwide erectile function questionnaire-5, MD = intend distinction, PRISMA-P = Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols, QoL = top quality of life, RCT = randomized regulated trial, RR = danger proportion.

How to point out this article: Yang F, Dong L, Zhang X, Li J, Tan K, Li Y, Yu X. Vasectomy and also male sexual dysfunction risk: A methodical evaluation and also meta-evaluation. Medicine. 2020;99:37(e22149).

This is a methodical review and also no moral approval compelled.

This job-related was supported by the National Natural Science Foundation of China (Grant Number: 81973647), the Funds of Science Growth of Chengdu College of Classic Chinese Medicine (Item Number: 2018yky12).

Tright here are no disputes of interemainder between the authors of this paper.

Documents sharing not applicable to this post as no datasets were created or analyzed in the time of the present study.

This is an open up accessibility write-up dispersed under the Creative Commons Attribution License 4.0 (CCBY), which permits unlimited usage, circulation, and remanufacturing in any kind of tool, offered the original work-related is effectively cited. http://creativecommons.org/licenses/by/4.0

Medicine: September 11, 2020 - Volume 99 - Issue 37 - p e22149
doi: 10.1097/MD.0000000000022149
Open Metrics



Unintended pregnancy is renowned anywhere the civilization, accounting for 40% to 50% of all pregnancies. The condition not just exerts pressure on the partnership of couples and severely results the top quality of life, yet additionally imposes a heavy burden on the wellness of womales and also child. Recently, even more than 220 million couples have preferred to be sterilized to acquire contraception, 47.3% of married couples pick sterilization, of which vasectomy accounts for 17.1%. Vasectomy is currently the the majority of convenient and reliable method of male contraception. We will perform the organized review and meta-evaluation to assess the correlation in between vasectomy and also male sex dysattribute and provide evidence-based evidence for the couple


The digital databases of MEDLINE, PubMed, Net of Science, EMBASE, Clinicaltrials.org., China National Knowledge Infrastructure Database (CNKI), Wan fang Database, China Biology Medicine Database (CBM), VIP Science Technology Periodical Database, Chinese Clinical Trial Regisattempt, and also Cochrane Library will be retrieved prior to November 20, 2021. We will certainly search English literary works and also Chinese literature through appropriate Medical Subject Heading or message essential words. RevMan 5.3 and also Stata 14.0 will be provided for Systematic review and Meta-evaluation. This protocol reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement, and we will report the organized review by following the PRISMA statement.

Conclusion and dissemination:

The aim of this research wregarding evaluate the effect of vasectomy on the sexual feature of patients after operation. The results will certainly be published in a public worry journal to administer evidence-based clinical evidence for urologists and andrologists to make clinical decisions.

Registration information:


1 Introduction

Unintfinished pregnancy is famous anywhere the world, accountancy for 40% to 50% of all pregnancies.<1> Whereas, numerous womales will pick to acquire abortions enduring the unintended pregnancy. The problem not only exerts push on the connection of couples and sevecount effects the quality of life (QoL), however also imposes a hefty burden on the wellness of women and son, such as damaging the mental health of woguys,<2> affecting subsequent pregnancy,<3> and also also inducing child maltherapy.<4> Therefore, picking proper contraception is crucial. Meanwhile, the approach of contraception is boosting as a result of the transforms in sexual tasks and refertile intentions.<5> More than 220 million couples have favored to be sterilized to obtain contraception, 47.3% of married couples select sterilization, of which tubal ligation accounts for 30.2% and also vasectomy accounts for 17.1%. Vasectomy, as the just develop of permanent male sterilization, the success price of it is 99.7%, via a lower incidence of complications of 1% to 2%.<6> This strategy is only applicable to males who execute not want to have youngsters later.

Vasectomy, which need to be done voluntarily, is presently the many convenient and also reliable approach of male contraception, mostly resulting from its simplicity, low invasiveness, performance, and also relatively low incidence of complications. Studies have actually presented that 96% of guys will certainly show serious oligospermia or azoospermia after 12 weeks of vasectomy,<7> and also common complications such as hematoma, infection, chronic scrotal pain, and pain at the surgical website and pain and also pressure occur within the abdomen.<6> A enormous number of researches have actually displayed that vasectomy did not affect male sexual attribute, and interestingly, had a positive result on the sexual function of the female partners.<8> A key variable may be the stress of woguys about undesirable pregnancies was reduced, and also women"s libiperform enhanced rather, and also they were even more willing to corun through males in sex.<9>

In the past, although numerous researches<10–13> have actually suggested that vasectomy is an reliable and safe option to get contraception, they still lack even more evidence to assistance this viewpoint. Hence, we will certainly perform the organized evaluation and meta-evaluation to assess the correlation in between vasectomy and male sex dysfunction and administer evidence-based proof for the couple who would favor to obtain the vasectomy to mitigate the concern, anxiety, and also depression of them.

2 Resee objectives

The objective of this research is to research the effect of vasectomy on male sex-related attribute. The testimonial of sexual function is largely carried out by the International erectile function questionnaire-5 (IIEF-5) and also general information questionnaire, collecting the data of sex-related desire, erectile feature, frequency, and also duration of sexual intercourse were gathered. This research will carry out more evidence to clarify the partnership between vasectomy and also erectile dysattribute.

3 Methods

This is a organized review, via a meta-evaluation if essential. The data and outcomes provided in this paper are almost from published studies, and also tright here are no moral problems, so the approval of the values committee is not forced.

3.1 Protocol and also registration

This examine is registered on PROSPERO. Registration number: CRD42020158346. This protocol refers to the statement of Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P).<14,15> And we will certainly report the methodical review by the PRISMA statement strictly.

3.2 File source

3.2.1 Electronic search database and strategy

The electronic databases of MEDLINE, PubMed, Net of Science, EMBASE, Clinicaltrials.org., China National Knowledge Infrastructure Database (CNKI), Wan fang Database, China Biology Medicine Database (CBM), VIP Science Technology Periodical Database, Chinese Clinical Trial Regisattempt, and Cochrane Library will be retrieved prior to November 20, 2021.

Grey literary works will be searched in Open Grey. Related randomized regulated trials (RCTs) will certainly be accumulated and also selected prior to November 20, 2021. The looking job-related will be done in December 2021 and updated before the systematic review has actually completed.

Medical Subject Heading or text crucial words “Vasectomy” or “Vasectomies” or “Vas Ligation” AND “Dysfeature, Erectile” or “Male Sexual Impotence” or “Impotence, Male Sexual” or “Sexual Impotence, Male” or “Male Impotence” or “Impotence, Male” or “Impotence” will certainly be used. The search strategy is readjusted to fit the various databases. The Chinese develop of the above terms will certainly be used in Chinese search. A specific search example for PubMed is summarized in Table 1.

Table 1:
PubMed search strategies.
3.2.2 Other sources of search

Grey literary works will be retrieved via Open Grey. The acquisition of full-message records needs library interlibrary loans and Google academic. A hands-on evaluation of references in published articles will be carried out to recognize other relevant research studies, and referrals detected from existing system reviews and also meta-analyses will likewise be retrieved.

3.3 Included and also excluded criteria

3.3.1 Study design

Randomized, double-blind, placebo-regulated trials would certainly be established the finest. Because this is surgical procedure, so it is difficult to accomplish random, managed for surgical procedure. As lengthy as the criteria of PRISMA are met, relevant clinical trials deserve to be systematically reregarded and also meta-evaluation can be performed if important. Thus, some various other suitable research kinds deserve to be included.

3.3.2 Participants

Included population

The mental health male patient that underwent a vasectomy. Before procedure, the sex-related feature of patients was normal. It would certainly be better if the sex-related attribute of the patients was evaluated authoritatively before the operation. Age >18 years.

Excluded population

Other contraceptive techniques are provided. Patients with some illness that deserve to cause sex-related dysfeature. Patients with psychological diseases, and also other associated illness or problems. 3.3.3 Interventions and also controls

Treatment group: All patients received vasectomy, regardless of the operation mode. Tbelow are no various other contraceptive methods and no various other factors resulting in sex-related dysattribute, including psychological components.

Control group: A placebo through the very same appearance as the treatment group or normal healthy world.

3.3.4 Outcomes

Key outcome indicator:

(1) IIEF. (2) Ejaculation feature (premature ejaculation, delayed ejaculation, non-ejaculation, ejaculation pain, etc). (3) Sexual desire.

Secondary outcome indicators:

(1) Postoperative pain scores. (2) QoL.

3.4 Selection of research studies and also information extraction

Document administration will certainly be conducted by Endnote X9 software program. The software program will certainly be offered to filter duplicate files first, and then delete duplicate records by reading titles, abstracts, and also other pertinent indevelopment.

According to the inclusion criteria and also exemption criteria, the literature will be better screened. In this procedure, the controversial literature will certainly be screened after obtaining the full text. Further thorough screening and also data extractivity of the records will certainly be carried out concurrently by 2 professionally trained reviewers.

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Then, the articles that satisfy the inclusion criteria are full-text read and also rescreened. If 2 or even more articles have repetitive or staged study results, only the short articles with the largest sample dimension, the the majority of finish treatment, and also follow-up time are contained. When the testimonial team cannot confirm the recurring studies, the original examine writer will be contacted for judgment. The flow chart of literature screening is presented in Fig. 1.